Selective functionalization by chemical methods at unactivated carbon atoms has been a major challenge in organic synthesis, and thus microbiological methods have frequently been used for this purpose. Biotransformations involve the use of enzymes or microorganisms to perform chemical reactions in which the starting substances and products are of comparable chemical complexity. On our studies, the secondary metabolites isolated from the medicinal plants, which showed the biological activities, are subjected for the biotransformation, and transformed products are purified and identified by spectroscopic analyses.
Thus obtained transformed compounds are further screened for the biological activities. We are working on derivatisation of natural secondary metabolites such as flavonoids and anthraquinones for enhancement of their bioactivities.
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For example, quercetin, a naturally occurring flavonoid, exhibits a high antioxidative property. Unfortunately its water insoluble property and the nature of rapid conjugation with glucuronosyltransferases and sulfotransferases present in the small intestine halts it to reach in the malignant organs through gastrointestinal tract in oral therapy. We have prepared several quercetin derivatives and compared their antioxidative property using the DPPH free radical scavenging assay.
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We also rationale the result obtained through the molecular calculations. Development of novel strategies for the synthesis of various target molecules is our another research topic. We have established all basic requirements to work on advanced organic synthesis.
Stereochemistry, Conformation, Synthesis, Biology, and Medicine
Cyclizations, nucleophilic additions, C-H activations and macrolide synthesis are our currently running projects. We achieved a landmark international publication on organic synthesis working solely in the country. We are focusing on development of economic, industrial processes. Avoiding of organic solvents and hazardous reagents, development of high yielding and atom economic process, the use of mild conditions and ease work up protocols, microwave synthesis and short step total synthesis are the goals.
Our achievements can be read in research articles and patents in the near future.
We provide analytical services to our customers from the government, private and academic institutions under nominal charges and mutual collaborations. Following facilities currently exist in our laboratories. Natural Products Chemistry. Home Natural Products Chemistry. The book can be used both as a text to introduce organic chemistry as it relates to plants and as a text of reference for more advanced readers.
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She has been a College level lecturer in organic chemistry for 32 years, teaching also non-majors plant chemistry and graduate courses in natural products chemistry. She has been an instructor of field seminars in plant chemistry for 15 years and a Docent at Regional Parks Botanic Garden for 15 years. Jump to main content.
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